Merck says COVID-19 pill cuts risk of death, hospitalization Are there any side effects from the COVID-19 vaccine? Like any vaccine, COVID-19 vaccines can cause mild, short term side effects, such as a low-grade fever or pain or redness at the injection site. Most reactions to vaccines are mild and go away within a few days on their own. More serious or long-lasting side effects to vaccines are possible but extremely rare.
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